Monograph Details
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Cardiovascular System
> CHF and arrhythmias
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Timolol maleate |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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β-blocker. |
| Generic Name |
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Timolol maleate 5mg, 10mg+, 20mg+; tabs; +scored. |
| Indications |
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In stabilized patients after MI, to reduce mortality and risk of reinfarction. |
| Children |
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Not recommended. |
| Adults |
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10mg twice daily. |
| Contraindications |
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Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. |
| Precautions |
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CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine. |
| Adverse Reactions |
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Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, decreased libido, chest pain, syncope, pruritus. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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