Monograph Details
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Cardiovascular System
> CHF and arrhythmias
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Quinidine sulfate |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Class I antiarrhythmic. |
| Generic Name |
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Quinidine sulfate 300mg; ext-rel tabs. |
| Indications |
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Atrial and ventricular arrhythmias (see literature). |
| Children |
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Not recommended. |
| Adults |
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Take with food and in an upright position. 300–600mg every 8–12 hrs. |
| Contraindications |
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Complete AV or bundle branch block or other severe intraventricular conduction defects. Myasthenia gravis. Arrhythmias due to digitalis intoxication. Aberrant impulses, abnormal rhythms due to escape mechanisms. |
| Precautions |
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Atrial flutter; digitalize first. Incomplete AV block. Marginally compensated cardiovascular disease. Heart failure. Hypotension. Renal or hepatic dysfunction. Monitor blood, liver and kidney function in long-term use. Monitor ECG and serum levels if dose is over 2.5g/day. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Toxicity increased by amiodarone, cimetidine, ranitidine, diuretics, carbonic anhydrase inhibitors, sodium bicarbonate, verapamil, diltiazem. Potentiates anticoagulants, anticholinergics, neuromuscular blocking agents, phenothiazines, reserpine, timolol. Increases digitalis serum levels. Plasma levels decreased by barbiturates, hydantoins, rifampin, nifedipine. |
| Adverse Reactions |
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Nausea, vomiting, abdominal pain, diarrhea, new or exacerbated arrhythmias, heart block, syncope, cinchonism, headache, blood dyscrasias, hypotension, flushing, impaired hearing and vision, allergic reactions, hepatic dysfunction. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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