Monograph Details
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Cardiovascular System
> CHF and arrhythmias
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MONOPRIL |
| Manufacturer |
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Bristol-Myers Squibb |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Fosinopril sodium 10mg+, 20mg, 40mg; tabs; +scored. |
| Indications |
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Adjunct to diuretics in heart failure, with or without digitalis. |
| Children |
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Contact manufacturer. |
| Adults |
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Initially 10mg once daily. Moderate to severe renal failure or volume depleted: initially 5mg once daily. Maintenance: 20–40mg once daily. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Salt/volume depletion. Renal or hepatic impairment. Monitor WBCs in renal or collagen vascular disease. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Monitor for hyperkalemia in diabetics. Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Surgery. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Potentiated by diuretics. Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Separate antacid dosing by 2 hrs. May cause false low serum digoxin measurements. |
| Adverse Reactions |
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Angina, orthostatic hypotension, dizziness, cough, GI upset, pain, hyperkalemia, upper respiratory infection, arrhythmias, asthenia; angioneurotic edema (discontinue if occurs). |
| How Supplied |
Tabs 10mg, 20mg—30, 90, 1000
40mg—30, 90 |
| Additional Resources |
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• Related Prescribing Note |
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