Monograph Details
|
|
Cardiovascular System
> CHF and arrhythmias
|
|
CAPOTEN |
| Manufacturer |
|
Par Pharmaceutical, Inc. |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
ACE inhibitor. |
| Generic Name |
|
Captopril 12.5mg, 25mg, 50mg, 100mg; scored tabs. |
| Indications |
|
Heart failure inadequately controlled by digitalis and diuretics. To reduce mortality in stable post-MI patients with left ventricular dysfunction (ejection fraction ≤40%). |
| Children |
|
Not recommended. |
| Adults |
|
Take 1 hr before meals. Heart failure: Initially 25mg 3 times daily (generally with diuretic and digitalis regimen). Increase, if needed, to 50mg 3 times daily. After 2 wks, may increase; max 450mg/day. Salt/volume depleted, or if systolic BP <100mmHg: Initially 6.25mg–12.5mg 3 times daily. Titrate to usual dose after several days. Post-MI: First dose 6.25mg 3 days post-MI, then increase to 12.5mg 3 times daily. Increase to 25mg 3 times daily over several days; maintenance 50mg 3 times daily. |
| Contraindications |
|
History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
|
Renal impairment. Salt/volume depletion. Dialysis (esp. high-flux membrane). CHF. Aortic stenosis. Monitor WBCs and renal function in renal and collagen vascular disease. Monitor for hyperkalemia in diabetics and renal insufficiency. Surgery. Discontinue if neutropenia, agranulocytosis, angioedema or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
|
Caution with K+-sparing diuretics and K+-containing supplements. May be antagonized by NSAIDs. Potentiated by diuretics, β-blockers, adrenergic antagonists. May increase lithium levels. May produce false (+) urinary acetone. |
| Adverse Reactions |
|
Headache, dysgeusia, rash, pruritus, dizziness, fatigue, cough, proteinuria, nephritis, GI upset, hyperkalemia, hyponatremia, back pain, tachycardia, excessive hypotension, dry mouth, jaundice, somnolence, sweating, sinusitis, impotence, angioedema. |
| How Supplied |
Tabs 25mg, 50mg—100, 1000
12.5mg, 100mg—100 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
