Monograph Details
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Cardiovascular System
> CHF and arrhythmias
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ACEON |
| Manufacturer |
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Solvay Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Perindopril erbumine 2mg, 4mg, 8mg; scored tabs. |
| Indications |
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To reduce risk of cardiovascular mortality or nonfatal MI in patients with stable coronary artery disease. |
| Children |
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Not recommended. |
| Adults |
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Initially 4mg once daily for 2 weeks, then increase as tolerated; maintenance: max 8mg once daily. Renal impairment: CrCl <30mL/min: not recommended; CrCl >30mL/min: initially 2mg/day: max 8mg/day. |
| Elderly |
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>70 yrs: initially 2mg once daily for 1st week, then 4mg once daily for 2nd week; maintenance: 8mg once daily, if tolerated. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal or hepatic impairment. Salt/volume depletion. Severe CHF. Renal artery or aortic stenosis. Monitor for neutropenia in renal or collagen vascular disease. Monitor for hyperkalemia in diabetics. Dialysis. Surgery. Discontinue if laryngeal edema, angioedema, marked elevations of liver enzymes or jaundice occurs. Black patients may have higher risk of angioedema than non-black patients. Elderly. Pregnancy (Cat.C in 1st trimester). Nursing mothers. |
| Interactions |
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Excessive hypotension with diuretics. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes, others (e.g., cyclosporine, indomethacin, heparin). May increase lithium levels. Caution with gentamicin, digoxin. |
| Adverse Reactions |
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Headache, cough, dizziness, sinusitis, viral infection, hypertonia, upper extremity pain, dyspepsia, fever, proteinuria, palpitations. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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