Monograph Details
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Cardiovascular System
> CHF and arrhythmias
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ACCUPRIL |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Quinapril (as HCl) 5mg+, 10mg, 20mg, 40mg; tabs; +scored. |
| Indications |
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Heart failure inadequately controlled by diuretics and/or digitalis. |
| Children |
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Not recommended. |
| Adults |
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Initially 5mg twice daily, if needed increase weekly to 20–40mg daily in 2 equally divided doses. In CHF with hyponatremia or renal impairment: initially 2.5–5mg once daily based on CrCl (see literature), if needed titrate dose under supervision. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Salt/volume depletion. Renal or hepatic impairment. CHF. Dialysis (esp. high-flux membrane). Monitor renal function in severe CHF, hypertension, or renal artery stenosis. Monitor WBCs in renal or collagen vascular disease. Monitor for hyperkalemia in diabetics. Surgery. Discontinue if angioedema or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers. |
| Interactions |
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K+ supplements, K+ sparing diuretics, K+ containing salt substitutes may cause hyperkalemia. May increase lithium levels. Antagonizes tetracycline. Potentiated by diuretics. |
| Adverse Reactions |
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Headache, dizziness, fatigue, cough, GI upset, hyperkalemia, back pain, tachycardia, dry mouth, somnolence, sweating, sinusitis. |
| How Supplied |
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Tabs—90 |
| Additional Resources |
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• Related Prescribing Note |
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