Monograph Details
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Cardiovascular System
> Angina
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TENORMIN |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cardioselective β-blocker. |
| Generic Name |
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Atenolol 25mg, 50mg, 100mg; tabs. |
| Indications |
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Long-term management of angina. |
| Children |
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Not recommended. |
| Adults |
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Initially 50mg once daily. May increase after 1 week to 100mg daily; max 200mg/day. Elderly or renal impairment: may need lower dose; monitor trough BP. Coincide a dose for the end of hemodialysis. |
| Contraindications |
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Sinus bradycardia. 2nd- or 3rd-degree heart block. Overt heart failure. Cardiogenic shock. |
| Precautions |
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Bronchospastic disease. Renal dysfunction. Diabetes. Hyperthyroidism. Pheochromocytoma. Surgery. Avoid abrupt cessation. Peripheral circulatory disorders. Ischemic heart disease or failure. Pregnancy (Cat.D): not recommended. Nursing mothers. |
| Interactions |
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Additive effect with catecholamine-depleting drugs, prazosin, digoxin. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Increased rebound hypertension with clonidine withdrawal. May block epinephrine. |
| Adverse Reactions |
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Heart failure, bronchospasm, bradycardia, angina, MI, heart block, dizziness, fatigue, GI upset, depression, orthostatic hypotension, cold extremities. |
| How Supplied |
Tabs 25mg, 100mg—100
50mg—100, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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