Monograph Details
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Cardiovascular System
> Angina
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MONOKET |
| Manufacturer |
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Schwarz Pharma, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nitrate. |
| Generic Name |
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Isosorbide mononitrate 10mg, 20mg; scored tabs. |
| Indications |
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Prophylaxis and treatment of angina. Not for acute attacks. |
| Children |
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Not recommended. |
| Adults |
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20mg upon awakening then 20mg 7 hrs later. Small patients: may start with 5mg per dose for 1 day, then increase to 10mg by 2nd or 3rd day (scheduled as above). |
| Contraindications |
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Concomitant sildenafil. |
| Precautions |
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Acute MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Monitor for tolerance. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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See Contraindications. Severe hypotension with sildenafil. Orthostatic hypotension with alcohol, other vasodilators, calcium channel blockers. |
| Adverse Reactions |
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Headache, dizziness, orthostatic hypotension, GI upset, upper respiratory infection. |
| How Supplied |
Tabs 10mg—100
20mg—100, 180 |
| Additional Resources |
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• Related Prescribing Note |
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