Monograph Details
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Cardiovascular System
> Angina
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LOPRESSOR |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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β-blocker. |
| Generic Name |
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Metoprolol tartrate 50mg, 100mg; scored tabs. |
| Indications |
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Long-term management of angina. |
| Children |
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Not recommended. |
| Adults |
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Take with meals. Initially 100mg daily in 2 divided doses. Increase, if needed, weekly. Usual range: 100–400mg/day. |
| Contraindications |
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Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. |
| Precautions |
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CHF. Bronchospastic disease, COPD. Hepatic dysfunction. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Bradycardia with catecholamine-depleting drugs. Potentiated by felodipine. May increase cardiac effects of calcium channel blockers, digitalis. Antagonized by NSAIDs, barbiturates, rifampin. May interfere with glaucoma screening tests. May block epinephrine. |
| Adverse Reactions |
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Fatigue, dizziness, depression, diarrhea, rash, dyspnea, bradycardia, cold extremities, palpitations, CHF, peripheral edema, hypotension, bronchospasm, heart block. |
| How Supplied |
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Tabs—100, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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