Monograph Details
|
|
Cardiovascular System
> Angina
|
|
Isosorbide dinitrate |
| Manufacturer |
|
Various generic manufacturers |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Nitrate. |
| Generic Name |
|
Isosorbide dinitrate 2.5mg, 5mg; sublingual tabs. |
| Also |
|
• ISORDIL TITRADOSE
|
| Indications |
|
Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina. |
| Children |
|
Not recommended. |
| Adults |
|
2.5–5mg sublingually 15 minutes before activity; allow a daily dose-free interval of at least 14 hours. |
| Contraindications |
|
Concomitant sildenafil. |
| Precautions |
|
Recent MI. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Monitor standing blood pressure when increasing doses. Tolerance may develop. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
|
See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers. |
| Adverse Reactions |
|
Headache, flushing, dizziness, weakness, orthostatic hypotension, paradoxical bradycardia, rash. |
| How Supplied |
Sublingual—contact supplier
Titradose 5mg, 10mg—100, 1000
20mg—100, 500
30mg, 40mg—100 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
