Monograph Details
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Cardiovascular System
> Angina
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ISORDIL TITRADOSE |
| Manufacturer |
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Biovail Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nitrate. |
| Generic Name |
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Isosorbide dinitrate 5mg, 10mg, 20mg, 30mg, 40mg; scored oral tabs. |
| Also |
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• Isosorbide dinitrate
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| Indications |
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Prophylaxis of angina. Not for acute attacks. |
| Children |
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Not recommended. |
| Adults |
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Initially 5–20mg 2–3 times per day. Maintenance: 10–40mg 2–3 times per day; allow a daily dose-free interval of at least 14 hours. |
| Contraindications |
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Concomitant sildenafil. |
| Precautions |
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Recent MI. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Monitor standing blood pressure when increasing doses. Tolerance may develop. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers. |
| Adverse Reactions |
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Headache, flushing, dizziness, weakness, orthostatic hypotension, paradoxical bradycardia, rash. |
| How Supplied |
Sublingual—contact supplier
Titradose 5mg, 10mg—100, 1000
20mg—100, 500
30mg, 40mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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