Monograph Details
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Cardiovascular System
> Angina
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INDERAL |
| Manufacturer |
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Akrimax Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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β-blocker. |
| Generic Name |
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Propranolol HCl 10mg, 20mg, 40mg, 60mg, 80mg; scored tabs. |
| Also |
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• INDERAL LA
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| Indications |
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Long-term management of angina. Hypertrophic subaortic stenosis. |
| Children |
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Not recommended. |
| Adults |
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Angina: 80–320mg/day divided into 2, 3, or 4 doses. Stenosis: 20–40mg 3–4 times a day before meals and at bedtime. |
| Contraindications |
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Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. |
| Precautions |
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CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests. |
| Adverse Reactions |
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Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis. |
| How Supplied |
Tabs 60mg—100
10mg, 20mg, 40mg, 80mg—100, 5000
LA—100 |
| Additional Resources |
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• Related Prescribing Note |
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