Monograph Details
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Cardiovascular System
> Angina
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DILATRATE-SR |
| Manufacturer |
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Schwarz Pharma, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nitrate. |
| Generic Name |
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Isosorbide dinitrate 40mg; sust rel caps. |
| Indications |
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Prophylaxis and treatment of angina. Not for acute attacks. |
| Children |
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Not recommended. |
| Adults |
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Take on empty stomach. See literature. Allow at least an 18-hour interval daily between doses to avoid development of tolerance. Max 160mg/day. |
| Contraindications |
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Concomitant sildenafil. |
| Precautions |
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Recent MI. CHF. Volume depletion. Hypotension. Hypertrophic cardiomyopathy. Monitor standing blood pressure when increasing doses. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers. |
| Adverse Reactions |
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Headache, flushing, dizziness, weakness, orthostatic hypotension, rash. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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