Monograph Details
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Cardiovascular System
> Angina
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CORGARD |
| Manufacturer |
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King Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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β-blocker. |
| Generic Name |
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Nadolol 20mg, 40mg, 80mg, 120mg, 160mg; scored tabs. |
| Indications |
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Long-term management of angina. |
| Children |
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Not recommended. |
| Adults |
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Initially 40mg once daily. May increase at 3–7 day intervals. Usual maintenance: 40–80mg once daily; max 240mg daily. Renal impairment: reduce dosage, see literature. |
| Contraindications |
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Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. CHF. |
| Precautions |
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Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Hypotension, bradycardia with catecholamine-depleting drugs, general anesthetics. May increase cardiac effects of calcium channel blockers, digitalis. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine. |
| Adverse Reactions |
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Bradycardia, dizziness, fatigue, cold extremities, heart failure, heart block, bronchospasm, GI upset, rash, pruritus. |
| How Supplied |
Tabs 20mg, 160mg—100
40mg, 80mg, 120mg—100, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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