Monograph Details
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Cardiovascular System
> Angina
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CARDIZEM CD |
| Manufacturer |
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Biovail Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (benzothiazepine). |
| Generic Name |
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Diltiazem HCl 120mg, 180mg, 240mg, 300mg, 360mg; ext-rel caps. |
| Also |
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• CARDIZEM LA
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| Indications |
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Vasospastic and chronic stable angina. |
| Children |
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Not recommended. |
| Adults |
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Initially 120–180mg once daily. Titrate over 7–14 days; usual max 480mg once daily. |
| Contraindications |
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Sick sinus syndrome, 2nd or 3rd degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission. |
| Precautions |
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Heart failure. Impaired renal or hepatic function (monitor). Obstructive hypertrophic cardiomyopathy. Discontinue if persistent rash occurs. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Potentiates propranolol, benzodiazepines, cyclosporine, carbamazepine, lovastatin (monitor). Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression. |
| Adverse Reactions |
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Edema, headache, fatigue, dizziness, asthenia, 1st degree AV block, bradycardia, flushing, nausea, rash (may be serious); rare: CHF, hypotension, liver abnormalities. |
| How Supplied |
LA tabs—7, 30, 90, 1000
CD 120mg, 180mg, 240mg, 300mg—30, 90
CD 360mg—90
Tabs 30mg, 60mg—100, 500
90mg, 120mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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