Browse Prescribing Notes by Therapeutic Subcategory

Enzymes (eg, Elspar, Oncaspar) deprive malignant cells of the asparagine necessary for protein synthesis, leading to cell death. Sequence of administration is critical when used in combination therapy.
Immunostimulants (eg, Thalomid, Revlimid) have direct antiproliferative and proapoptotic antitumor effects, inhibit TNFα and angiogenesis and stimulate T-cell production. Theracys induces a granulomatous reaction at the site of administration.
Differentiating agents (eg, retinoids, Trisenox) induce differentiation in tumor cell lines; a block in differentiation is one of the hallmarks of malignant transformation.
Photochemotherapy (eg, Uvadex, Photofrin) involves using photoactive substances followed by radiation resulting in injury or death to cancer cells.
Bisphosphonates (eg, Aredia, Zometa) may inhibit the activation of cancer-associated proteins through the suppression of geranyl-geranylation and farnesylation or inhibit proliferation by preventing pos-translational prenylation of Ras-related proteins.