Browse Prescribing Notes by Therapeutic Subcategory

Ethyol is dephosphorylated to the active free thiol metabolite form which is able to bind and detoxify reactive metabolites of cisplatin and scavenge reactive oxygen species generated by exposure to either cisplatin or radiation.
Zinecard is converted intracellularly to a ring-opened chelating agent that interferes with iron-mediated free radical generation responsible for anthracycline induced cardiomyopathy.
Leucovorin counteracts the therapeutic and toxic effects of folic acid antagonists (eg, methotrexate) which act by inhibiting dihydrofolate reductase and can enhance the therapeutic and toxic effects of fluoropyrimidines (eg, 5-FU).
Mesnex reacts chemically with the urotoxic ifosfamide metabolites (acrolein and 4-hydroxy-ifosfamide) in the kidney resulting in detoxification.