Monograph Details
|
|
Allergic Disorders
> Anaphylaxis
|
|
TWINJECT |
| Manufacturer |
|
Sciele Pharma, Inc. |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Sympathomimetic. |
| Generic Name |
|
Epinephrine (1:1000); 0.15mg/injection, 0.3mg/injection; auto-injection device; contains sulfites. |
| Indications |
|
Emergency treatment of anaphylaxis. |
| Adults and Children |
|
IM or SC inj into thigh. <15kg: not recommended. 15–30kg: 0.15mg. ≥30kg: 0.3mg. May repeat if needed; 2nd dose must be given manually (only the 1st injection is automatic). |
| Precautions |
|
Cardiovascular disease. Hypertension. Hyperthyroidism. Diabetes. Parkinson's disease. Advise patient to seek medical help immediately. Train patient in use of device. Elderly. Pregnancy (Cat.C). |
| Interactions |
|
Potentiated by tricyclics, MAOIs, levothyroxine, antihistamines. Antagonized by β-blockers, α-blockers. Cardiac arrhythmias possible with concomitant digitalis, diuretics, antiarrhythmics. Pressor effects may be reversed by ergots, phenothiazines. |
| Adverse Reactions |
|
Tachycardia, sweating, nausea, vomiting, respiratory difficulty, pallor, dizziness, weakness, tremor, headache, nervousness, anxiety, arrhythmia. |
| How Supplied |
|
Auto-injector syringe (2 injections/syringe)—1, 2 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
